Читать книгу Biomolecular Engineering Solutions for Renewable Specialty Chemicals - Группа авторов - Страница 71

Mitochondrial‐dependent apoptosis is an important pathway for the induction of apoptosis, and any disturbance in this pathway could inhibit apoptosis. The apoptosis pathway is regulated by the B‐cell lymphoma‐2 (Bcl‐2) family proteins and this Bcl‐2 regulates (elevation or downregulation) the mitochondrial membrane permeability for the release of cytochrome‐c and other apoptotic proteins. Furthermore, caspase activation and DNA fragmentation are the main features of induced apoptosis. Xie et al. (2020) have shown that vanilla‐containing food‐induced apoptosis in HT‐29 colon cancer cells by inducing oxidative damage and also modulated the expression of apoptotic markers. Gupta et al. (2010) have reported that vanilla and vanilla‐containing food downregulates Bcl‐2, which causes upregulation of Bax and thereby increases the permeability of the mitochondria to apoptosis‐inducing factor (AIF), which is then released to cytosol from the mitochondria. AIF in the cytosol‐activated caspases‐3, 7, and 9, which causes DNA fragmentation and finally induced cell death by apoptosis.