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A Distribution of alveolar ventilation

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 The distribution of alveolar ventilation, or the change in alveolar size with each breath, is not uniform throughout the lung due to differences in the mechanical properties of the lung and chest wall.

 In the standing horse, the intrapleural pressure is more sub‐atmospheric in the dorsal part of the lung relative to the ventral part, due to the effect of gravity on lung tissue. The alveoli in the dorsal part of the lung are therefore more distended, and less compliant than in the ventral part of the lung. As a result, alveolar ventilation per unit change in pressure is greater in the ventral compared to the dorsal part of the lung.The alveoli in the dorsal aspect of the lung would be at a location further to the right on the curve. (see Figure 4.3)Figure 4.3 Pulmonary pressure‐volume curve; illustrating greater pressure difference required for inspiration than for expiration (squares = inspiration; circles = expiration).

Manual of Equine Anesthesia and Analgesia

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