Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 49

 ALP is present in biliary epithelial cells, hepatocytes, bone, placenta, and intestine.

 The reference range for the horse is 119–329 U/l.

 Activity originates from induction similar to GGT, but it is not liver specific.However, most serum ALP is derived from the liver, and the remainder is from bone, and a small amount from intestine.

 Increase in ALP activity indicates cholestasis from intra or extrahepatic causes.But increases are more likely if the obstruction is extrahepatic.

 Intestinal lesions can also increase ALP activity.

 Bone growth causes an increase in serum ALP activity.

 ALP in serum is highest at birth and decreases over the first month to adult range by two to four years.The increased ALP activity in neonatal foals may be of placental origin.