Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 58

 Albumin is the main protein present in plasma.

 The reference range is 2.7–3.7 g/dl.

 Its main function is the regulation of the colloidal osmotic pressure (COP) of blood.

 It accounts for 75–80% of the COP of normal plasma, although it only comprises 50–60% of the total protein content of plasma.

 The oncotic effect of albumin is enhanced by its ability, due to its negative charge, to attract cations, particularly Na+.This is termed the Gibbs‐Donnan effect.

  Albumin is the smallest plasma protein in molecular weight (~66 kDa).

 Albumin binds water, ions, fatty acids, hormones, bilirubin, and therapeutic compounds.

 It is synthetized by the liver and has a plasma half‐life of approximately 19 days in the horse.

 Albumin is classified as a negative acute phase reactant because its production is down‐regulated during inflammation.