Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 63

 Fibrinogen is an important soluble glycoprotein that is synthetized by the liver.

 It is a plasma clotting factor precursor which is converted to fibrin on contact with a sticky surface.The fibrin threads formed in this way trap platelets to form the primary platelet clot on which a stable blood clot is formed by the process of coagulation.

 Fibrinogen is a positive acute phase reactant, and it can be used to diagnose and monitor inflammatory conditions.

 Reference range is 2–4 g/l.

 Plasma fibrinogen concentrations can increase up to 10‐fold in an inflammatory process.The half‐life of fibrinogen is ~three days.

 Foals may have increased concentrations up to six months of age.

 Pregnant mares may have increases of up to 40%, and fibrinogen may further increase in the immediate postpartum period, before returning to normal in about two weeks post‐foaling.