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 SDH is a cytoplasmic enzyme, and it acts as a catalyst in the conversion of sorbitol to fructose.

 SDH activity is low, and the majority comes from the hepatocyte.

 SDH is a “leakage” enzyme released when hepatocytes are damaged.

 Thus, SDH is considered a specific indicator of liver damage, especially acute damage.

 SDH has a short half‐life (hours), so serum concentrations fall quickly.It is generally not increased in chronic liver disease.

 It is a labile enzyme, and its activity decreases with time.However, it is stable in serum for up to five hours when refrigerated.

 Reference range: 1–8 U/l.