Читать книгу Drug Transporters - Группа авторов - Страница 118

A relatively unique feature of the SLC22 family of genes is that many members tend to appear as pairs or clusters in the genome [48–51]. For example, some of the known OATs are found in three tightly linked pairs (i.e., as adjoining neighbors without other genes interposed between them): SLC22A6—SLC22A8, SLC22A9—SLC22A10, and SLC22A11—SLC22A12. The SLC22A6—SLC22A8 pair is found as a tandem repeat on human chromosome 11q12.3. In addition, SLC22A6 and SLC22A8, together with other less well‐characterized transporters in the SLC22 family (e.g., SLC22A9, SLC22A10, SLC22A24, and SLC22A25), are found clustered together in a 0.6 megabase region on human chromosome 11 in order from centromere to telomere [6]. The SLC22A11—SLC22A12 pair is also found in a tandem repeat (separated by less than 20 kilobase pairs) and is also located on human chromosome 11 (11q13.1), but it is about a million base pairs away from the SLC22A6—SLC22A8 cluster. Nevertheless, these observations raise the possibility that the chromosomal arrangement of these OAT genes might exist to facilitate the coordinated transcription (co‐regulation) of pair‐members [5, 6, 50].