Читать книгу Drug Transporters - Группа авторов - Страница 121

While Oats were initially shown to be predominantly expressed in the kidney [32], it is now clear that these transporters are found in most barrier epithelia of the body, including the choroid plexus, blood–brain barrier, biliary tract, intestine, retinal–blood barrier, the nose–brain barrier, blood–testis barrier, the maternal‐fetal barrier among others (Table 4.1) [23, 24]. Within these various tissues, the OATs facilitate the active movement of signaling molecules, endogenous metabolites, vitamins, natural products, many commonly prescribed pharmaceuticals, as well as exogenous and endogenous toxins. Thus, based on their extensive tissue distribution, the OATs must be considered important mediators of endogenous homeostasis, pharmaco‐ and toxicokinetics. Due to the aforementioned role in movement of small molecules and expression patterns, it has been hypothesized that these transporters participate in a broader remote sensing and signaling network between organs (see below for more detail on the Remote Sensing and Signaling Theory) [48, 51, 62].