Читать книгу Drug Transporters - Группа авторов - Страница 130

The main physiological role of the OATs now appears to be the maintenance of the basal physiological state through their regulation of the movement and concentrations of key endogenous metabolites (e.g., nutrients, vitamins, antioxidants, gut microbiome products, signaling molecules, and neurotransmitters). Indeed, a wide variety of metabolites (e.g., α‐ketoglutarate), signaling molecules (e.g., cGMP, odorants, conjugated sex steroids, prostaglandins, bile acids), dietary compounds (e.g., flavonoids, folate, pantothenate), antioxidants (e.g., urate), and molecules originating in the gut microbiome (e.g., indoxyl sulfate, hippurate) bind Oats, and many of these same molecules accumulate in the Oat1 and Oat3 knockouts [37, 120, 124].