Читать книгу Drug Transporters - Группа авторов - Страница 72

Octn3 transports carnitine independent of sodium, with a K _m of 3 μM in reconstituted proteoliposomes containing ATP [110]. Carnitine transport is stimulated by ATP and is largely pH independent. Octn3 also transports acetylcarnitine. Significant inhibition of Octn3‐mediated carnitine transport has been observed by acetylcholine, TEA, butyric acid, GABA, betaine, butyrobetaine, acetylcarnitine, and palmitoylcarnitine. The chicken ortholog of Octn3 exhibits similar characteristics, demonstrating sodium‐independent carnitine transport in enterocytes and basolateral membrane vesicles (BLMV) isolated from chicken intestinal epithelia [111].