Читать книгу Drug Transporters - Группа авторов - Страница 85

A number of drugs that alter cardiovascular function are substrates for MATE transporters. For example, beta‐adrenergic agonist/antagonist drugs, such as fenoterol, atenolol, nadolol and salbutamol, are substrates for hMATE1 and hMATE2‐K [41, 42]. Notably, transport of these drugs tends to be higher capacity, lower affinity, and with moderate stereoselectivity compared with OCT‐type transporters [41]. Dual expression of hOCT2 and hMATE1 in MDCK cells enabled the transepithelial transport of atenolol compared to control cells [43]. These data suggest that this transporter system is responsible for the renal secretion of atenolol.