Читать книгу Drug Transporters - Группа авторов - Страница 73

In mouse, rat, and chicken enterocytes, Octn3 is located at the basolateral membrane, contrary to the localization of OCTN2 to the apical membrane [1]. Octn3 transcription in mice is mediated by PPARα in the kidney and small intestine, but not the testes [82]. Octn3 expression is dependent on binding of the zinc finger transcription factor Sp1 in mice; the disruption of this site suppresses transcription [1].