Читать книгу Drug Transporters - Группа авторов - Страница 86

Alkaloid drugs are used clinically for their anticholinergic properties for diseases such as chronic obstructive pulmonary disease, asthma, ocular disorders, and gastrointestinal illness. In particular, the quaternary amine derivatives of alkaloids, namely ipratropium and trospium, are transported by MATE transporters. The transcellular transport of ipratropium and trospium is accomplished by hMATE1 in combination with either hOCT1 or hOCT2 in MDCKII cells [44, 45]. These studies may provide insights into the hepatic and/or renal clearance of alkaloid‐type drugs.