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In 2006, Enders reported a seminal paper on organocatalyst‐mediated domino reaction (Eq. 1.27) [53]. He reported an excellent domino reaction catalyzed by diphenylprolinol silyl ether, wherein three reactions such as Michael/Michael/intramolecular aldol condensation reactions take place in one pot to provide cyclohexene carbaldehydes bearing four stereogenic centers with excellent stereocontrol. Rather complex skeletons were synthesized only by mixing the substrates via a domino reaction.

Enders’ group reported many useful domino reactions [54]. For instance, functionalized complex tricyclic polyethers were synthesized by one‐pot quadruple domino oxa‐Michael/Michael/Michael/aldol condensation/hetero‐Diels‐Alder reaction in nearly enantiomerically pure form (Eq. 1.28) [55]. Tetracyclic pyridocarbazole derivatives were synthesized by the three‐component triple cascade reaction such as Diels‐Alder/aza‐Michael/intramolecular aldol condensation reactions with excellent enantioselectivity (Eq. 1.29) [56].

(1.27)

(1.28)

(1.29)