Читать книгу Catalytic Asymmetric Synthesis - Группа авторов - Страница 39

Metal catalysts are widely used in organic synthesis, and a combination of metal catalyst with enamine and iminium ion intermediates opens a new avenue for the synthetic organic chemistry [69]. However, there are limitations to the use of organocatalysts and metal catalysts cooperatively. In organocatalytic reactions involving an enamine as an intermediate, water would be generated in the reaction, and organometallic catalysts have to act efficiently under these reaction conditions. Moreover, the organocatalyst is usually an amine, and metal catalysts also have to catalyze the reaction in the presence of organo amine catalyst. In spite of these limitations, several successful reactions have been developed using a combination of organocatalyst and metal catalyst.