Читать книгу Catalytic Asymmetric Synthesis - Группа авторов - Страница 43

After the discovery of the proline‐mediated intermolecular aldol reaction and organocatalyst‐mediated Diels‐Alder reaction in 2000, the basic concept of reactions involving an enamine and an iminium ion has become established. Since these first reactions, domino reactions using organocatalysts have developed dramatically and complex skeletons have been constructed with excellent enantioselectivity in a single pot. The application of organocatalyst‐mediated reactions to total syntheses of natural products and drugs is another recent advancement. Combination of organocatalyst and other catalysts is another developing field, and many successful reactions have been reported. Given that enamines and iminium ions are useful intermediates, many reactions involving these intermediates await to be developed. I hope this chapter will encourage further development in organocatalytic reactions.