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A domino Michael/Henry reaction of succinaldehyde and nitroalkene in the presence of diphenylprolinol silyl ether proceeded to afford substituted cyclopentanecarbaldehyde, which was further treated with Horner‐Wadsworth‐Emmons reagent to provide a cyclopentane derivative with excellent enantioselectivity in a one‐pot operation (Eq. 1.35). This is a key intermediate for the synthesis of prostaglandin E₁ methyl ester, which was synthesized using a total of three reaction vessels [63].

(1.35)