Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 176

This method of granulocyte collection is described because of historical interest, but it is not used today. A nylon fiber filter system was developed to collect granulocytes [76]. Although this system yielded a larger number of cells than the centrifuge procedures, granulocytes obtained by filtration leukapheresis had a mild‐to‐moderate functional impairment and decreased intravascular recovery and survival [77, 78]. Also, a severe transient neutropenia occurred a few minutes after the donor’s blood came into contact with the nylon fibers [78–81] due to activation of the complement system [81, 82]. Reports of donor complications [83] led to the discontinuation of filtration leukapheresis.