Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 183

The major clinical symptoms of PBSC collection on donors are caused by the G‐CSF the donors receive to mobilize the PBSCs. Almost all donors experience some side effect [73]. The most common of these is bone pain, but headache, fatigue, and flu‐like symptoms also occur. In response to G‐CSF, the donor’s leukocyte count increases to 30,000–40,000 per microliter, and the platelet count decreases by about 40% [120, 121]. The leukocyte and platelet counts return to normal by about day 16, or about 10 days after the apheresis donation and discontinuation of G‐CSF. There is an increase in alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase, and sodium, and a decrease in glucose, potassium, bilirubin, and blood urea nitrogen. In donors who receive G‐CSF, the spleen size increases [122] and splenic rupture has been reported [123]. Although most donors experience some side effects, these are mild and should interfere with PBSC donation only rarely.

Recently, it has been suggested that platelet and MNC donors may experience prolonged lymphopenia after repeated donations [124]. It is unclear whether this effect is instrument dependent and/or related to other factors such as donor age, and studies are ongoing. Thus far, there appear to be no reports of medical complications associated with this apparent lymphopenia.