Читать книгу Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide - Laura Shane-McWhorter - Страница 27

There are only a few published studies using fenugreek. Most of these are short-term, involve very few patients, and do not adequately report details. In one study, 10 patients on insulin (with type 1 diabetes) were included in a 10-day evaluation.⁸¹ The patients were assigned to either placebo or twice-daily 50 g fenugreek defatted seed powder, used in unleavened bread. Fasting glucose decreased from an average of 272 mg/dl (15.1 mmol/l) at baseline to 196 mg/dl (10.9 mmol/l; P < 0.01). Total cholesterol decreased (P < 0.001), as did LDL and triglycerides (P < 0.01 for both).

A larger study involved a 6-month trial of fenugreek in 60 patients with inadequately controlled type 2 diabetes.⁸² Fenugreek seed powder, 25 g daily, was given in two equal doses at lunch and dinner. The average fasting glucose decreased from 151 mg/dl (8.4 mmol/l) to 112 mg/dl (6.2 mmol/l) after 6 months. Glucose values 1 and 2 hours after meals also declined. Mean baseline 1-hour glucose measured by oral glucose tolerance test (OGTT) was 245 mg/dl (13.6 mmol/l) at the start of the study and decreased to 196 mg/dl (10.9 mmol/l) after 6 months (P < 0.001). Mean 2-hour glucose decreased from 257 mg/dl (14.3 mmol/l) to 171 mg/dl (9.5 mmol/l; P < 0.001). Average A1C decreased from 9.6% to 8.4% after 8 weeks (P < 0.001).

In a different study, 25 newly diagnosed type 2 diabetes patients were given a hydroalcoholic fenugreek extract or placebo plus usual care of diet and exercise for 2 months.⁸³ The group assigned to fenugreek was given 1 g/day of the seed extract. The fenugreek group did not differ from the placebo group in fasting or postprandial glucose, although they had improved area under the curve blood glucose and insulin levels (P < 0.001) and an improved lipid profile for triglycerides and HDL.