Читать книгу Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide - Laura Shane-McWhorter - Страница 42

Trials studying nopal are small and have mostly been published in Spanish, although abstracts are available in English. One trial was done in three groups of type 2 diabetes patients treated with diet alone or in combination with sulfonylureas.¹⁰⁷ Oral medications were discontinued 72 hours before nopal was administered. After a 12-hour fast, one group of 16 patients received 500 g broiled nopal, a second group of 10 received 400 ml water, and a third group of 6 received 500 g broiled zucchini. Subjects had blood drawn at 60, 120, and 180 minutes after receiving the nopal, water, or zucchini. The nopal group had a significant decline from 222 mg/dl (12.3 mmol/l) fasting to 203 mg/dl (11.3 mmol/l), 198 mg/dl (11.0 mmol/l), and 183 mg/dl (10.2 mmol/l), respectively, at 60, 120, and 180 minutes after receiving the treatment (P < 0.001 compared with baseline).¹⁰⁷

Another trial compared the effects of nopal in 14 patients on sulfonylureas to the effects in individuals without diabetes. Individuals in both groups received 500 g broiled nopal or 400 ml water. In the diabetes group, glucose declined by 21 mg/dl (1.2 mmol/l), 28 mg/dl (1.6 mmol/l), and 41 mg/dl (2.3 mmol/l) at 60, 120, and 180 minutes after nopal was administered (P < 0.005 for 60 and 120 minutes vs. baseline; P < 0.001 for 180 minutes vs. baseline).¹⁰⁸ Insulin concentrations also declined significantly.