Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 208

Ivermectin and other macrocyclic lactones cause toxicity in mammals by acting as GABAA-receptor agonists in the CNS. Low CNS concentrations of macrocyclic lactones produce stimulatory CNS effects (e.g. tremors, seizures), whereas higher concentrations result in inhibitory CNS effects (e.g. ataxia, obtundation, stupor, coma).