Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 218

Methylxanthines enhance catecholamine effects both directly and indirectly through phosphodiesterase inhibition, elevation in intracellular cyclic AMP (AMPc) and increased calcium influx into neurons (O’Brien, 1998). This results in increased neuromuscular excitability and a positive inotropic effect. Competitive inhibition of cellular adenosine receptors further increases intracellular AMPc and results in CNS stimulation.