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Clinical signs of ivermectin toxicity have been reported at dosages ranging from 0.1 to 0.4 mg/kg PO in ABCB1 gene mutation-susceptible canine breeds, 0.2–2.5 mg/kg PO in non-susceptible canine breeds and of 0.3 mg/kg SC in cats (Merola and Eubig, 2012). Clinical signs include obtundation, disorientation, hypersalivation, muscle tremors, ataxia, blindness, mydriasis, seizures, stupor and coma (Hopper et al., 2002; Nelson et al., 2003; Kenny et al., 2008; Merola et al., 2009). Due to the long half-life of macro-cyclic lactones (from 2 days for ivermectin to 19 days for moxidectin), clinical signs of toxicosis may persist for days to weeks, depending on the agent, dose and the breed involved. Death may occur from respiratory arrest if no therapeutic intervention takes place.