Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 80

Insulin secreting pancreatic β-islet cell neoplasia is the most common cause of hypoglycaemia-induced seizures in adult dogs. Feline insulinoma is rare. These tumours are associated with excess insulin secretion independent of the negative feedback effects caused by hypoglycaemia. Hyperinsulinaemia produces hypoglycaemia through suppression of glucose release and production rather than increased glucose utilization (Goutal et al., 2012). Most canine insulinomas are malignant. Metastatic lesions have been detected in 45% to 64% of dogs in different studies and most dogs have involvement of regional lymph nodes with or without distant metastases (commonly in the liver) by the time insulinoma is diagnosed (Hess, 2010). Insulinoma has been reported predominantly in adult to old dogs (mean age of 9 years) and in medium- to large-breed dogs.