Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 81

Clinical signs are related to insulin-induced neuroglycopenia (seizures, generalized weakness, collapse, ataxia, obtundation and impaired vision) and/or to hypoglycaemia-induced catecholamine release (tremors, nervousness and hunger) (Goutal et al., 2012). Clinical signs can occur intermittently (Hess, 2010). Fasting, excitement or exercise can precipitate or worsen clinical signs by decreasing blood glucose concentration. Feeding can result in either alleviation (when restoring normoglycaemia) or exacerbation (by stimulating insulin secretion) of clinical signs (Hess, 2010). A peripheral polyneuropathy has been described in dogs with insulinoma and may be caused by an immune mediated paraneoplastic process or by glucose-mediated metabolic disturbances in the lower motor neurons.