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Morphine

Оглавление

 Pharmacology:Poorly lipid soluble.Hepatic metabolism with active metabolite morphine‐6‐glucuronide.Renally eliminated.Onset of action 5–10 minutes, duration of effect 4–5 hours.Elimination half‐life 3–4 hours.

 Drug‐specific side effects:Accumulation can occur in renal failure.Can cause clinically significant histamine release.

 Recommended doses:Bolus: 2–4 mg IV every 1–2 hours.Infusion: 2–30 mg/h.PCA: bolus 0.5–3 mg, lockout interval 10–20 minutes.

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