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 Pharmacology:Synthetic opioid with antagonism of NMDA receptors along with usual agonism of opioid receptors.Hepatic metabolism and renal elimination.No active metabolites.Onset of action 10–20 minutes, duration of effect 6–8 hours.Elimination half‐life 15–60 hours.

 Drug‐specific side effects:QTc prolongation: ECG monitoring is recommended while using this drug.

 Recommended doses:Bolus: 10–40 mg every 6–12 hours.Infusion: not recommended.