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 Pharmacology:High lipid solubility.Active metabolites.Only benzodiazepine formulation without propylene glycol as solvent.Metabolized by several cytochrome P450 enzymes.Onset of action 2–5 minutes, duration of effect 1–2 hours.Elimination half‐life 3–11 hours, significant CSHT.Cessation of effect is due to redistribution.

 Drug‐specific side effects:Renal elimination of active metabolites.

 Recommended doses:Bolus: 0.01–0.05 mg/kg.Infusion: 0.02–0.1 mg/kg/h.