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 Pharmacology:No active metabolites.Onset of action 15–20 minutes, duration of effect 1–2 hours.Elimination half‐life 3–11 hours.

 Drug‐specific side effects:Typical solutions contain propylene glycol that can cause metabolic acidosis and acute kidney injury when run as an infusion. A serum osmolar gap greater than 10–12 mOsm/L suggests propylene glycol toxicity.

 Recommended doses:Bolus: 0.02–0.04 mg/kg (maximum dose 2 mg) every 2–6 hours as required.Infusion (generally not recommended): 0.01–0.1 mg/kg/h (maximum dose <10 mg/h).