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 Pharmacology:Active metabolites.Onset of action 2–5 minutes IV, peak effect 1‐2 hours, duration of effect variable but typically 4–6 hours.Can be given per rectum for seizure treatment if no intravenous access.Elimination half‐life 20+ hours due to active metabolites.

 Drug‐specific side effects:Respiratory depression.Phlebitis.Uses propylene glycol as solvent.Accumulation of metabolites in renal failure.

 Recommended doses:Bolus: 5–10 mg IV.PRN dosing: 0.03–0.1 mg/kg every 0.5–6 hours.Rectal dose for seizures: 0.2 mg/kg seizures, every 4–12 hours as required, status epilepticus 0.5 mg/kg bolus and 0.25 mg/kg every 10 minutes as required.