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1 Barr J, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013; 41(1):263–306.

2 Devlin JW, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018; 46:e825–73.

3 Joffe AM, McNulty B, Boitor M, Marsh R, Gélinas C. Validation of the critical‐care pain observation tool in brain‐injured critically ill adults. J Crit Care 2016; 36:76–80.

4 Khan BA, et al. Comparison and agreement between the Richmond Agitation‐Sedation Scale and the Riker Sedation‐Agitation Scale in evaluating patients’ eligibility for delirium assessment in the ICU. Chest 2012; 142(1):48–54.

5 Kotifs K, Zegan‐Baranska M, Szydlowski L, Zukowski M, Ely EW. Methods of pain assessment in adult intensive care unit patients – Polish version of CPOT (Critical Care Pain Observation Tool) and BPS (Behavioral Pain Scale). Anaesthesiol Intensive Ther 2017; 49(1):66–72.

6 Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM. Posttraumatic stress disorder in critical illness survivors. Crit Care Med 2015; 43(5):1121–9.

7 Patanwala AE, Martin JR, Erstad BL. Ketamine for analgosedation in the intensive care unit: a systematic review. J Intensive Care Med 2017; 32(6):387–95.

8 Payen J, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 2001; 29(12):2258–63.

9 Reade MC, et al. for the DahLIA Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Effect of dexmedetomidine added to standard care on ventilator‐free time in patients with agitated delirium: a randomized clinical trial. JAMA 2016; 315(14):1460–8.

10 Turunen H, et al. Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation. Crit Care 2015; 19(1):67.

Additional material for this chapter can be found online at: www.wiley.com/go/mayer/mountsinai/criticalcare

This includes multiple choice questions.