Читать книгу Mount Sinai Expert Guides - Группа авторов - Страница 49

 Pharmacology:Alpha‐2 receptor agonist.Minimal respiratory depression.Hypnotic and analgesic properties.No active metabolites.Onset of action after loading dose 5–10 minutes.

 Side effects:Hypertension: often associated with loading doses.Hypotension: often associated with loading doses.Bradycardia.

 Recommended doses:Loading dose: 1 μg/kg over 10 minutes.

Infusion: FDA approved for 0.2–0.7 μg/kg/h for up to 24 hours; reports have shown safety with maximum infusion 1.5 μg/kg/h for up to 1 month.

 Miscellaneous:No proven benefit to delirium.