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Polymeric nanoparticles are synthesized by the spontaneous aggregation of copolymers with unlikely hydrophobicity in the micelles forming core shell in the aqueous medium (Figure 3.6). They facilitate the encapsulation of lipophilic or hydrophilic drug molecules, nucleic acids, peptides, and smaller molecules to completely strengthen the drug protection in the systemic circulation. Usually they are biocompatible and systemic degradable particle of 10 to 1000 nm in size. They are used as carriers for sustained and controlled drug delivery by modifying the surface of the nanoparticle for passive and active target delivery [36].