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The two major factors that affect the personalized medicine application are the choice of drug and technology tool to opt as a part of genetic testing and the validation of the choice of drug and the tool. As discussed above, the wise use of nanotechnology tools in customizing drug delivery improves the currently existing drug therapy by increasing the patient compliances and reducing the adverse drug reaction and side effects. It also emphasizes the need of pharmacogenetic and pharmacogenomic data for a better excise of the diagnostic, prevention, and treatment models present. An implication of nanotechnological tools in personalized medicines is the initial growth in the field of clinical and patient care approaches. Still, various undiscovered technologies by utilizing genetic data that are available for decades are the future upcoming scopes for better therapy of diseases. The collaborated researches combining nanotechnologies, biotechnology, and the concept of personalized medicines yields a patient-centric diagnosis and treatment technology. From the traditionally available conventional dosage forms such as tablets, capsules, and ointments, solutions are being customized by introducing nanodrug delivery incorporated into the available delivery systems in accordance with the patient’s diagnostic needs for better accurate treatment. In the future, the booming field of personalized medicines and the existing nanotechnology approach an increased application for the treatment of patient-centric drug delivery.