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They are macromolecules that are naturally or synthetically branched compositions of amino acids, nucleotides, and saccharides (Figure 3.8). They are structured with an exterior outer surface, following the inner branched layers and centrally contain the core. They are synthesized by controlled polymerization to produce monodispersed highly branched polymer system. The cavities of the branched polymers in the core are loaded with small molecules by chemical bondage or hydrophobic linkage or by simple hydrogen bonding. They vary in size NMT 10 nm. They serve the positivity of their controlled delivery of biologically active agents targeting the macrophages and hepatic tissues [38].

Figure 3.8 Dendrimers.