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Extranodal NK/T‐cell Lymphomas

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Extranodal NK/T‐cell lymphoma (ENKTCL) is most commonly seen in Asia, Central and South America (Peru and Mexico), and Mexico, where it accounts for 5–10% of all NHLs [48, 49, 58, 59]. It is most commonly associated with EBV positivity [60]. ENKTCL is a rare disorder in the United States, Europe, South Asia, the Middle East, and Africa. In the United States, the incidence is greater in Hispanic Whites and Asian/Pacific Islanders than in African Americans, non‐Hispanic Whites, and American Indian/Alaskan natives [18]. The most common site of presentation is nasal cavity followed by skin.

The median age at presentation in Asia is 52 years (ranges from 44 to 54 years) [61] whereas median age at presentation in the United States is relatively older, around 64 years [18]. There is a male predominance with an approximately two to one male to female ratio [61, 62].

The Peripheral T-Cell Lymphomas

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