Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 105

HSTL was initially called hepatosplenic gamma–delta T‐cell lymphoma, but with identification of the alpha/beta T‐cell receptor in the liver, sinusoids of spleen and bone marrow, it was subsequently reclassified as HSTL. It is a very rare neoplasm, which usually has an aggressive course and carries a poor prognosis. HSTL accounts for less than 1% of NHL [9]. Only a few cases are reported in the literature, so the exact incidence is unknown [79]. It appears to have a male predominance with a median age at diagnosis of approximately 35 years [80]. Approximately, 15–20% of patients diagnosed with HSTL are known to be on prolonged immune‐suppressive therapy in the setting of solid organ transplantation, and inflammatory bowel disease [81, 82].