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 The T‐cell lymphomas are characterized by marked differences in its global patterns of distribution.

 While the endemic distribution of viruses like human T‐cell lymphotropic virus type I (HTLV1) and Epstein–Barr virus may help explain some of the geographic variability, the biological basis for the marked differences in incidence across countries is poorly understood.

 T‐cell lymphomas like extranodal natural‐killer T‐cell lymphoma and HTLV1 adult T‐cell leukemia/lymphoma have a much higher incidence and prevalence in Asia and the Caribbean, and are considered relative rare in the West.

 The incidence of peripheral T‐cell lymphoma may have increased over the past two decades in the United States, some fraction of which may be due to better diagnosis.

The Peripheral T-Cell Lymphomas

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