Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 88

Over the years, murine models have played crucial roles as versatile tools for detailed investigation of T‐cell lymphomas. We now have a deeper understanding of the underlying mechanisms, disease pathogenesis and potential therapeutic interventions. Nevertheless, it is essential to understand the limitations of these model systems. Lack of precise simulation of the human disease and the microenvironment in mice are few among many shortcomings that hinder the success of novel drugs in clinical trials. The advent of targeted genetic manipulation using novel technologies may eventually resolve and refine the remaining differences making mouse the ultimate model organism of choice to study human ailments.