Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 104

In combination, EATL and monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) account for approximately 5% of all T/NK‐cell lymphomas [10, 51, 77]. In the past, EATL was classified into two subtypes. Type I is associated with celiac disease and type II is designated by lack of association with celiac disease. Both types originate from intraepithelial T cells of intestinal origin. The most recent 2017 WHO classification recognized type II EATL as a separate entity, now referred to as MEITL, based on its histologic characteristics [9]. EATL is primarily seen in individuals of northern European origin, where there is a higher incidence of celiac disease, whereas MEITL is a relatively aggressive type and is more frequently reported from Asia, but with apparent increase in frequency in individuals of Hispanic origin [78]. Individuals with celiac disease that is not adequately treated or is untreated have a higher incidence of developing EATL.