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The batch process is a customized form of batch fermentation. It is the most popular mode of operation of fermentation in the bioprocessing sector. Microorganisms are inoculated and cultivated under the batch system for a period of time after the introduction of nutrients to the fermenter in order to feed them. Fermentation is interrupted only when the fermentation broth volume approaches 75% of the bioreactor volume [86]. In the fed‐batch systems, the steady feed flow of the media substrate enables the target secondary metabolites to achieve very high concentrations/levels. The benefit of this method of culturing is that the fed substrate level can be managed at the target level (very often relatively low) [87]. This will allow the prevention of undesirable changes, like changes responsible for substrate inhibition or changes in cellular metabolism at a high concentration of substrate. Also, fed‐batch systems can be applied when large amounts of biomass are required [88, 89].