Читать книгу Cosmeceuticals - Группа авторов - Страница 10

Cosmeceuticals represent one of the fastest growing segments of personal care products. Advances in the field of skin biology and pharmacology have facilitated the development of novel active compounds. The increase in the number of active ingredients delivered topically through the skin has led to a heightened importance of understanding the mechanisms of delivery of those active ingredients. Ideal delivery of actives aims at a high delivery capacity, formulation stability, and minimal side effects. There are two pathways for the delivery of cosmeceuticals: transepidermal and a transappendageal pathways. Delivery systems can be divided into active systems and passive systems. Active systems use physical enhancement methods, like sonophoresis, ionophoresis, micro-needling, micro-dermabrasion, and ablative, nonablative, and fractional laser delivery methods. Passive systems utilize chemical delivery methods including chemical penetration enhancers, emulsions, vesicular lipid-based systems, and lipid particulate carrier systems. Here we review the mechanisms of delivery of active ingredients through the skin and the systems by which they are delivered through the epidermis.

© 2021 S. Karger AG, Basel

The stratum corneum (SC) provides a strong barrier to drug delivery. This is especially problematic for relatively large molecules with a molecular mass larger than 500 Da [1]. Overcoming the skin barrier in a safe and effective way is the goal of transcutaneous delivery systems [2]. Topical drug delivery heavily depends on the ability of active ingredients to permeate the skin in sufficient quantities to achieve their desired therapeutic effects. Transcutaneous delivery of medications and active ingredients has gained an unprecedented popularity in the past decade due to demand for targeted and localized delivery with minimal side effects [3].