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The first generation of vesicular-based systems are liposomes, which were first described by Mezei and Gulasekharam [31] in 1980. A liposome is formed by a lipid bilayer surrounding an aqueous solution (Fig. 2) and can range in size between 200 and 800 nm [29, 32]. Drug delivery using these carriers is mainly limited by their rigidity and size, which can impede SC penetration. Liposomes more than 600 nm in size do not penetrate deeply and remain in the SC. Their advantages lie in the wide variety of drugs that can be incorporated as well as their biocompatibility with natural phospholipids. Examples of drugs delivered throughout the skin using liposomes are curcumin and retinoic acid [33–35]. Furthermore, liposomes have been utilized to deliver siRNA through the skin and impact protein expression at basal keratinocytes [36].