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The transepidermal pathway consists of intercellular and intracellular pathways. Intercellular pathways involve solute diffusion through the intercellular lipid domains (Fig. 1) [4]. Multiple studies report that intercellular lipids, and not the corneocyte proteins, are the main epidermal permeability barrier. The intracellular (transcellular) pathway involves permeation through the corneocytes followed by the intercellular lipids [5]. The permeation through corneocytes entails creation of an aqueous pore through degradation of corneodesmosomes. This route is therefore believed to prefer hydrophilic compounds for delivery. Occlusion, ultrasound waves, and ionophoresis can increase this form of permeation [6].