Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 355

 No study has been published examining these drugs in seizure‐prone horses, but the following points are taken from studies performed in other species.

 Xylazine (0.5–1.0 mg/kg, IV) or detomidine (10–15 μg/kg, IV) can be used as a premedicant.Xylazine has been shown in other species to have proconvulsant activity at low doses and anticonvulsant activity at sedative doses.

 Acepromazine was once not recommended because other phenothiazines have been shown to reduce the seizure threshold, but acepromazine has been used successfully in seizure‐prone dogs.

 Ketamine increases the chance of seizures in patients with a known history of seizure activity, although it has been used to treat seizures refractory to conventional treatment. However, ketamine may be the only choice available for induction of anesthesia in adult horses because thiopental is now not widely available.Since diazepam is an anticonvulsant, the combined use of diazepam/ketamine is safe. Alternatively, propofol/ketamine is safe to use.

 Guaifenesin may be used in seizure‐prone horses. Triple drip (α2‐ agonist/guaifenesin and ketamine combination) may be used for short diagnostic procedures with tracheal intubation and lung ventilation.