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B Synthesis, duration of action, and degradation of ACh

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 ACh is synthesized within the axoplasm in the terminal endings of cholinergic nerves.

 The ACh is transported to the interior of the vesicles where it is stored in a highly concentrated form until it is released along with ATP.

 After release, ACh persists in the tissue for a few seconds, then most of it is split into an acetate ion and choline by the enzyme acetylcholinesterase, which is present in the terminal neuron and the surface of the receptor organ.

Manual of Equine Anesthesia and Analgesia

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