Читать книгу Manual of Equine Anesthesia and Analgesia - Группа авторов - Страница 365

 Synthesis of norepinephrine from phenylalanine begins in the axoplasm of the terminal nerve endings of adrenergic nerve fibers and is completed inside the vesicles.

 In the adrenal medulla, this reaction goes one step further and transforms about 85% of the norepinephrine into epinephrine.

 After secretion, NE is rapidly (within a few seconds) removed from the secretory site and taken back to the vesicles, either unchanged or metabolized by monoamine oxidase (MAO). If it reaches the circulation, NE, and also EPI, are metabolized by MAO and catechol‐O‐methyltransferase (CMT) in the liver and kidney.