Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 158

Enzymes can cleave the sugars that confer A and B specificities [157, 158]. The enzymes for this cleavage have been cloned and are available on a scale sufficient to allow for the production of clinical doses of red cells from which the A and B antigens have been removed. Most of the experience involves successful conversion of group B to group O [157]. Although A‐to‐O conversion is possible, some A determinants remained on the carbohydrate, and this work was halted. Clinical trials of enzymatically converted B type RBCs on healthy volunteers reported no signs of hemolysis [157].