Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 159

A different approach to altering the RBC membrane to convert group A or B red cells into group O red cells is to mask the antigens to produce “stealth” red cells. Polyethylene glycol has been used to covalently bond to red cells to mask blood group antigens, such as ABO, Rh, Kell, and Kidd [159]. Small studies in animals suggest that there is little in vitro damage to the red cells and that they have a normal survival, although such studies have not yet been carried out in humans. It is not clear whether development of this process will continue.